Translational research on influenza virus infection using a nonhuman primate model
Identifieur interne : 000466 ( Main/Exploration ); précédent : 000465; suivant : 000467Translational research on influenza virus infection using a nonhuman primate model
Auteurs : Yasushi Itoh [Japon]Source :
- Pathology International [ 1320-5463 ] ; 2016-03.
Abstract
Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (NHP) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. NHPs have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an NHP model, we revealed that the pandemic 2009 influenza A virus caused viral pneumonia as reported in human patients. Thus, it is thought that NHP models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. NHP models have provided promising results in research on other infectious diseases including Ebola virus and human/simian immunodeficiency virus infections. Thus, NHPs are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using NHP models in this review.
Url:
DOI: 10.1111/pin.12385
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001449
- to stream Istex, to step Curation: 001449
- to stream Istex, to step Checkpoint: 000000
- to stream Main, to step Merge: 000466
- to stream Main, to step Curation: 000466
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Translational research on influenza virus infection using a nonhuman primate model</title><author><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CCBCA2A9D0C5D56061DEA4B703212E94C072AC0D</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1111/pin.12385</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-LXGCBHKS-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001449</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001449</idno><idno type="wicri:Area/Istex/Curation">001449</idno><idno type="wicri:Area/Istex/Checkpoint">000000</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000000</idno><idno type="wicri:doubleKey">1320-5463:2016:Itoh Y:translational:research:on</idno><idno type="wicri:Area/Main/Merge">000466</idno><idno type="wicri:Area/Main/Curation">000466</idno><idno type="wicri:Area/Main/Exploration">000466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Translational research on influenza virus infection using a nonhuman primate model</title><author><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Shiga University of Medical Science, Shiga, Otsu</wicri:regionArea><wicri:noRegion>Otsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pathology International</title><title level="j" type="alt">PATHOLOGY INTERNATIONAL</title><idno type="ISSN">1320-5463</idno><idno type="eISSN">1440-1827</idno><imprint><biblScope unit="vol">66</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="132">132</biblScope><biblScope unit="page" to="141">141</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2016-03">2016-03</date></imprint><idno type="ISSN">1320-5463</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1320-5463</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (NHP) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. NHPs have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an NHP model, we revealed that the pandemic 2009 influenza A virus caused viral pneumonia as reported in human patients. Thus, it is thought that NHP models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. NHP models have provided promising results in research on other infectious diseases including Ebola virus and human/simian immunodeficiency virus infections. Thus, NHPs are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using NHP models in this review.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name></noRegion><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000466 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000466 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:CCBCA2A9D0C5D56061DEA4B703212E94C072AC0D
|texte= Translational research on influenza virus infection using a nonhuman primate model
}}
| This area was generated with Dilib version V0.6.33. |  |